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Journal Articles
Journal articles and book chapters

Selected journal articles and book chapter authored or co-authored by Dr. Petr Kuzmic.

Articles are arranged chronologically with the most recent item on the top of the list.


  1. "Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance"
    Schwartz, PA; Kuzmic, P; Solowiej, J; Bergqvist, S; Bolanos, B; Almaden, C; Nagata, A; Ryan, K; Feng, JL; Dalvie, D; Kath, JC; Xu, MR; Wani, R; Murray, BW (2014)
    Proc. Natl. Acad. Sci. U. S. A. 111, 173-178 [PDF]

  2. "Nonlinear Regression Models for Determination of Nicotinamide Adenine Dinucleotide Content in Human Embryonic Stem Cells"
    Salykin, A; Kuzmic, P; Kyrylenko, O; Musilova, J; Glatz, Z; Dvorak, P; Kyrylenko, S (2013)
    Stem Cell Rev. Rep. 9, 786-793 [PDF]

  3. "Homotropic Cooperativity from the Activation Pathway of the Allosteric Ligand-Responsive Regulatory trp RNA-Binding Attenuation Protein"
    Kleckner, IR; Mcelroy, CA; Kuzmic, P; Gollnick, P; Foster, MP (2013)
    Biochemistry 52, 8855-8865 [PDF]

  4. "A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin"
    Rothnie, A; Clarke, AR; Kuzmic, P; Cameron, A; Smith, CJ (2011)
    Proc. Natl. Acad. Sci. U. S. A. 108, 6927-6932 [PDF]

  5. "Optimal design for the dose-response screening of tight-binding enzyme inhibitors"
    Kuzmic, P (2011)
    Anal. Biochem. 419, 117-122 [PDF]

  6. "A generalized numerical approach to steady-state enzyme kinetics: Applications to protein kinase inhibition"
    Kuzmic, P (2010)
    BBA-Proteins Proteomics 1804, 635-641 [PDF]

  7. "Detection of enzyme-catalyzed polysaccharide synthesis on surfaces"
    Cle, C; Martin, C; Field, RA; Kuzmic, P; Bornemann, S (2010)
    Biocatal. Biotransform. 28, 64-71 [PDF]

  8. "Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases"
    Sexton, DJ; Chen, T; Martik, D; Kuzmic, P; Kuang, G; Chen, J; Nixon, AE; Zuraw, BL; Forteza, RM; Abraham, WM; Wood, CR (2009)
    Biochem. J. 422, 383-392 [PDF]

  9. "Application of the Van Slyke-Cullen irreversible mechanism in the analysis of enzymatic progress curves"
    Kuzmic, P (2009)
    Anal. Biochem. 394, 287-289 [PDF]

  10. "Dynafit-a software package for enzymology"
    Kuzmic, P (2009)
    Methods Enzymol. 467, 247-280 [PDF]

  11. "Analysis of residuals from enzyme kinetic and protein folding experiments in the presence of correlated experimental noise"
    Kuzmic, P; Lorenz, T; Reinstein, J (2009)
    Anal. Biochem. 395, 1-7 [PDF]

  12. "Complexation between Methyl Viologen (Paraquat) Bis(Hexafluorophosphate) and Dibenzo[24]Crown-8 Revisited"
    Gasa, TB; Spruell, JM; Dichtel, WR; Sorensen, TJ; Philp, D; Stoddart, JF; Kuzmic, P (2009)
    Chem.-Eur. J. 15, 106-116 [PDF]

  13. "A steady state mathematical model for stepwise "slow-binding" reversible enzyme inhibition"
    Kuzmic, P (2008)
    Anal. Biochem. 380, 5-12 [PDF]

  14. "CYP2E1 substrate inhibition - Mechanistic interpretation through an effector site for monocyclic compounds"
    Collom, SL; Laddusaw, RM; Burch, AM; Kuzmic, P; Perry, MD; Miller, GP (2008)
    J. Biol. Chem. 283, 3487-3496 [PDF]

  15. "Structural and mechanistic changes along an engineered path from metallo to nonmetallo 3-deoxy-D-manno-octulosonate 8-phosphate synthases"
    Kona, F; Xu, XJ; Martin, P; Kuzmic, P; Gatti, DL (2007)
    Biochemistry 46, 4532-4544 [PDF]

  16. "Global analysis of protein-protein interactions reveals multiple CYP2E1 - Reductase complexes"
    Jamakhandi, AP; Kuzmic, P; Sanders, DE; Miller, GP (2007)
    Biochemistry 46, 10192-10201 [PDF]

  17. "Self-assembled small-molecule microarrays for protease screening and profiling"
    Urbina, HD; Debaene, F; Jost, B; Bole-feysot, C; Mason, DE; Kuzmic, P; Harris, JL; Winssinger, N (2006)
    ChemBioChem 7, 1790-1797 [PDF]

  18. "A generalized numerical approach to rapid-equilibrium enzyme kinetics: Application to 17 beta-HSD"
    Kuzmic, P (2006)
    Mol. Cell. Endocrinol. 248, 172-181 [PDF]

  19. "Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides"
    Kuzmic, P; Cregar, L; Millis, SZ; Goldman, M (2006)
    FEBS J. 273, 3054-3062 [PDF]

  20. "Mechanism of loading the Escherichia coli DNA polymerase III sliding clamp - I. Two distinct activities for individual ATP sites in the gamma complex"
    Williams, CR; Snyder, AK; Kuzmic, P; O'donnell, M; Bloom, LB (2004)
    J. Biol. Chem. 279, 4376-4385 [PDF]

  21. "Discovery of cationic inhibitors of anthrax lethal factor protease."
    Tang, C; Simo, O; O'malley, S; Nagata, M; Goldman, M; Cregar, L; Nguyen, D; Kuzmic, P; Moayeri, M; Leppla, S; Liddington, R; Hemscheidt, T; Jiao, GS (2004)
    Abstr. Pap. Am. Chem. Soc. 228, U967-U968

  22. "Practical robust fit of enzyme inhibition data"
    Kuzmic, P; Hill, C; Janc, JW (2004)
    Methods Enzymol. 383, 366-381 [PDF]

  23. "Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: Evidence for a role in hookworm-associated growth delay"
    Chu, D; Bungiro, RD; Ibanez, M; Harrison, LM; Campodonico, E; Jones, BF; Mieszczanek, J; Kuzmic, P; Cappello, M (2004)
    Infect. Immun. 72, 2214-2221 [PDF]

  24. "Effect of ribavirin and amantadine on early hepatitis C virus RNA rebound and clearance in serum during daily high-dose interferon"
    Lake-bakaar, G; Ruffini, L; Kuzmic, P (2003)
    Dig. Dis. Sci. 48, 126-139 [PDF]

  25. "Kinetic determination of tight-binding impurities in enzyme inhibitors"
    Kuzmic, P; Hill, C; Kirtley, MP; Janc, JW (2003)
    Anal. Biochem. 319, 272-279 [PDF]

  26. "Molecular characterization of Ancylostoma inhibitors of coagulation factor Xa - Hookworm anticoagulant activity in vitro predicts parasite bloodfeeding in vivo"
    Harrison, LM; Nerlinger, A; Bungiro, RD; Cordova, JL; Kuzmic, P; Cappello, M (2002)
    J. Biol. Chem. 277, 6223-6229 [PDF]

  27. "A detailed physical map of the 6p reading disability locus, including new markers and confirmation of recombination suppression"
    Ahn, J; Won, TW; Kaplan, DE; Londin, ER; Kuzmic, P; Gelernter, J; Gruen, JR (2002)
    Hum. Genet. 111, 339-349 [PDF]

  28. "The effect of combining interferon, ribavirin and amantadine an hepatitis C viral dynamics: Further evidence that ribavirin and amantadine block de novo re-infection."
    Lake-bakaar, G; Ruffini, L; Kuzmic, P (2001)
    Gastroenterology 120, A29-A29

  29. "A broad spectrum Kunitz type serine protease inhibitor secreted by the hookworm Ancylostoma ceylanicum"
    Milstone, AM; Harrison, LM; Bungiro, RD; Kuzmic, P; Cappello, M (2000)
    J. Biol. Chem. 275, 29391-29399 [PDF]

  30. "Early HCV RNA 'rebound' during daily high dose interferon treatment: Inhibition by ribavirin."
    Lake-bakaar, G; Ruffini, L; Kuzmic, P (2000)
    Gastroenterology 118, A946-A946

  31. "Dynamics of HLA-1 Beta-2-microglobulin subunit during treatment with high dose interferon with or without ribavirin: Correlation with serum HCV RNA and ALT."
    Lake-bakaar, GV; Rufini, L; Kuzmic, P (2000)
    Gastroenterology 118, A940-A940

  32. "HCV viral dynamics during therapy with high dose interferon-A-2B plus or minus ribavirin: Correlation with ALT suggests ribavirin may suppress early de novo re-infection."
    Lake-bakaar, GV; Ruffini, L; Kuzmic, P (2000)
    Gastroenterology 118, A1016-A1016

  33. "High-throughput screening of enzyme inhibitors: Automatic determination of light-binding inhibition constants"
    Kuzmic, P; Sideris, S; Cregar, LM; Elrod, KC; Rice, KD; Janc, JW (2000)
    Anal. Biochem. 281, 62-67 [PDF]

  34. "High-throughput screening of enzyme inhibitors: Simultaneous determination of tight-binding inhibition constants and enzyme concentration"
    Kuzmic, P; Elrod, KC; Cregar, LM; Sideris, S; Rai, R; Janc, JW (2000)
    Anal. Biochem. 286, 45-50 [PDF]

  35. "General numerical treatment of competitive binding kinetics: Application to thrombin-dehydrothrombin-hirudin"
    Kuzmic, P (1999)
    Anal. Biochem. 267, 17-23 [PDF]

  36. "Fixed-point methods for computing the equilibrium composition of complex biochemical mixtures"
    Kuzmic, P (1998)
    Biochem. J. 331, 571-575 [PDF]

  37. "Inhibition of human steroid 5 alpha reductases type I and II by 6-aza-steroids: Structural determinants of one-step vs two-step mechanism"
    Moss, ML; Kuzmic, P; Stuart, JD; Tian, GC; Peranteau, AG; Frye, SV; Kadwell, SH; Kost, TA; Overton, LK; Patel, IR (1996)
    Biochemistry 35, 3457-3464 [PDF]

  38. "Program DYNAFIT for the analysis of enzyme kinetic data: Application to HIV proteinase"
    Kuzmic, P (1996)
    Anal. Biochem. 237, 260-273 [PDF]

  39. "Mechanical effects on the kinetics of the HIV proteinase deactivation"
    Kuzmic, P; Peranteau, AG; Garciaecheverria, C; Rich, DH (1996)
    Biochem. Biophys. Res. Commun. 221, 313-317 [PDF]

  40. "Increase in fluorescence upon the hydrolysis of tyrosine peptides - application to proteinase assays"
    Peranteau, AG; Kuzmic, P; Angell, Y; Garciaecheverria, C; Rich, DH (1995)
    Anal. Biochem. 227, 242-245 [PDF]

  41. "Radical reduction of c-cl bonds in chlorofluoro ethers"
    Liska, F; Fikar, J; Kuzmic, P (1993)
    Collect. Czech. Chem. Commun. 58, 565-574

  42. "Kinetic assay for hiv proteinase subunit dissociation"
    Kuzmic, P (1993)
    Biochem. Biophys. Res. Commun. 191, 998-1003 [PDF]

  43. "Stabilization of hiv proteinase dimer by bound substrate"
    Kuzmic, P; Garciaecheverria, C; Rich, DH (1993)
    Biochem. Biophys. Res. Commun. 194, 301-305 [PDF]

  44. "A continuous spectrophotometric direct assay for peptidyl prolyl cis-trans-isomerases"
    Garciaecheverria, C; Kofron, JL; Kuzmic, P; Rich, DH (1993)
    Biochem. Biophys. Res. Commun. 191, 70-75 [PDF]

  45. "Effect of lithium-chloride on conformational equilibria in peptidyl prolyl cis-trans isomerase substrates and inhibitors"
    Rich, DH; Kofron, J; Kishore, V; Kuzmic, P; Garciaecheverria, C; Fesik, SW; Gemmecker, G (1992)
    Abstr. Pap. Am. Chem. Soc. 203, 149-ORGN

  46. "Identification of actin and hsp-70 as cyclosporine-a binding-proteins by photoaffinity-labeling and fluorescence displacement assays"
    Moss, ML; Palmer, RE; Kuzmic, P; Dunlap, BE; Henzel, W; Kofron, JL; Mellon, WS; Royer, CA; Rich, DH (1992)
    J. Biol. Chem. 267, 22054-22059 [PDF]

  47. "Mixtures of tight-binding enzyme-inhibitors - kinetic-analysis by a recursive rate-equation"
    Kuzmic, P; Ng, KY; Heath, TD (1992)
    Anal. Biochem. 200, 68-73 [PDF]

  48. "Fluorescence displacement method for the determination of receptor ligand-binding constants"
    Kuzmic, P; Moss, ML; Kofron, JL; Rich, DH (1992)
    Anal. Biochem. 205, 65-69 [PDF]

  49. "Lithium-chloride perturbation of cis-trans peptide-bond equilibria - effect on conformational equilibria in cyclosporine-a and on time-dependent inhibition of cyclophilin"
    Kofron, JL; Kuzmic, P; Kishore, V; Gemmecker, G; Fesik, SW; Rich, DH (1992)
    J. Am. Chem. Soc. 114, 2670-2675 [PDF]

  50. "Continuous fluorometric direct (uncoupled) assay for peptidyl prolyl cis-trans-isomerases"
    Garciaecheverria, C; Kofron, JL; Kuzmic, P; Kishore, V; Rich, DH (1992)
    J. Am. Chem. Soc. 114, 2758-2759 [PDF]

  51. "Long-range electrostatic effects in pepsin catalysis"
    Kuzmic, P; Sun, CQ; Zhao, ZC; Rich, DH (1991)
    Tetrahedron 47, 2519-2534 [PDF]

  52. "Determination of kinetic constants for peptidyl prolyl cis trans isomerases by an improved spectrophotometric assay"
    Kofron, JL; Kuzmic, P; Kishore, V; Colonbonilla, E; Rich, DH (1991)
    Biochemistry 30, 6127-6134 [PDF]

  53. "Regioselectivity of nucleophilic aromatic photosubstitution in the biphenyl series - photohydrolysis of some dimethoxynitrobiphenyls"
    Urban, J; Kuzmic, P; Saman, D; Soucek, M (1987)
    Collect. Czech. Chem. Commun. 52, 2482-2491

  54. "Substituent effects in aromatic photochemistry - uv irradiation of 3,4-dimethoxybenzonitrile and 3,4-dimethoxyacetophenone in the presence of inorganic anions"
    Kuzmic, P; Soucek, M (1987)
    Collect. Czech. Chem. Commun. 52, 980-988

  55. "Photoreaction of n-butyl 3,4-dimethoxy-6-nitrobenzamide with butylamine - a model study for lysine-directed photoaffinity-labeling"
    Kuzmic, P; Pavlickova, L; Soucek, M (1987)
    Collect. Czech. Chem. Commun. 52, 1780-1785

  56. "Chemical actinometry in the uv range based on the photohydrolysis of 3,4-dimethoxynitrobenzene"
    Pavlickova, L; Kuzmic, P; Soucek, M (1986)
    Collect. Czech. Chem. Commun. 51, 368-374

  57. "Photochemical hydrolysis of some nitrophenyl acetates"
    Kuzmic, P; Pavlickova, L; Soucek, M (1986)
    Collect. Czech. Chem. Commun. 51, 1293-1300 [PDF]

  58. "Photoreaction of 3,4-dimethoxy-1-nitrobenzene with butylamine - a ph-dependence of regioselectivity"
    Kuzmic, P; Pavlickova, L; Velek, J; Soucek, M (1986)
    Collect. Czech. Chem. Commun. 51, 1665-1670

  59. "Photocyanation of 3,4-dimethoxy-1-nitrobenzene - a quantitative study"
    Kuzmic, P; Soucek, M (1986)
    Collect. Czech. Chem. Commun. 51, 358-367


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