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Lectures and Seminars

A selection of invited talks given by Dr. Petr Kuzmic:

University of Massachusetts Medical School, April 2015 University of Massachusetts Medical School, April 2015
Brandeis University, December 2014 Brandeis University, December 2014
AstraZeneca, September 2014 AstraZeneca, September 2014
Brandeis University, March 2014 Brandeis University, March 2014
Archive Archive

Note: Several most recent talks address the same topic, so there is significant overlap. However each presentation attempts to address the topic from a slightly different perspective.


University of Massachusetts Medical School, April 2015Top of pageNext section
  • A New 'Microscopic' Look at Steady-state Enzyme Kinetics
    University of Massachusetts Medical School, Worcester MA, April 6, 2015

  • Topics: Steady-state enzyme kinetics revisited; Direct determination of microscopic rate constants from initial rate data; Inosine-5'-monophosphate dehydrogenase inhibition

    PDF handout | PDF notes | PowerPoint presentation


Brandeis University, December 2014Top of pageNext section
  • New Insights into Covalent Enzyme Inhibition: Application to Anti-Cancer Drug Design
    Brandeis University, Waltham MA, December 5, 2014

  • Topics: EGFR inhibition by covalent drugs (PNAS, January 2014); Various substrate catalytic mechanisms considered; The effect of association rate constant

    PDF handout | PowerPoint presentation


AstraZeneca, September 2014Top of pageNext section
  • Covalent Inhibition Kinetics: Application to EGFR Kinase
    AstraZeneca Global R&D, Alderley Park, U.K., September 23, 2014

  • Topics: EGFR inhibition by covalent drugs (PNAS, January 2014); Data quality control algorithm; Confidence intervals for "on" and "orr" constants

    PDF handout | PowerPoint presentation


Brandeis University, March 2014Top of pageNext section
  • Irreversible Inhibition Kinetics: Biochemical Rate Constants vs. Cell-based IC50
    Brandeis University, Waltham MA, March 20, 2014

  • Topics: EGFR inhibition by covalent drugs (PNAS, January 2014); New results using previously published data; PK/PD simulations

    PDF handout | PowerPoint presentation


ArchiveTop of pageNext section
Archived older lectures and seminars:
  • Irreversible Inhibition Kinetics: Automation and Simulation
    PDF handout | PowerPoint presentation

  • Numerical Enzymology: Generalized Treatment of Kinetics and Equilibria
    PDF handout | PowerPoint presentation

  • Why IC50's Are Bad for You and Other Surprises
    PDF handout | PowerPoint presentation

  • Numerical Enzyme Kinetics: Using DynaFit Software
    PDF handout | PowerPoint presentation

  • Biochemical / Biophysical Kinetics Made Easy
    PDF handout | PowerPoint presentation

  • DynaFit in the Analysis of Enzyme Progress Curves: Irreversible Enzyme Inhibition
    PDF handout | PowerPoint presentation

  • Biochemical Kinetics Made Easier: DynaFit Applications to Protein Kinases
    PDF handout | PowerPoint presentation

  • Optimal Experiment Design for Dose-Response Screening of Enzyme Inhibitors
    PDF handout | PowerPoint presentation

  • Evolutionary Computing in the Study of Bio/Chemical Mechanisms
    PDF handout | PowerPoint presentation

  • Bio/Chemical Kinetics Made Easier: A Numerical Approach
    PDF handout | PowerPoint presentation

  • Numerical Enzymology: Generalized Treatment of Kinetics and Equilibria
    PDF handout | PowerPoint presentation

  • Advanced Methods in Dose-Response Screening of Enzyme Inhibitors
    PDF handout | PowerPoint presentation


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Tue Nov 29 15:18:28 2016