A selection of invited talks given by Dr. Petr Kuzmic:

University of Massachusetts Medical School, April 2015
Brandeis University, December 2014
AstraZeneca, September 2014
Brandeis University, March 2014
Archive

Note: Several most recent talks address the same topic, so there is significant overlap. However each presentation attempts to address the topic from a slightly different perspective.

University of Massachusetts Medical School, April 2015

• A New 'Microscopic' Look at Steady-state Enzyme Kinetics
  University of Massachusetts Medical School, Worcester MA, April 6, 2015
  
  
• Topics: Steady-state enzyme kinetics revisited; Direct determination of microscopic rate constants from initial rate data; Inosine-5'-monophosphate dehydrogenase inhibition
  
  PDF handout | PDF notes | PowerPoint presentation

Brandeis University, December 2014

• New Insights into Covalent Enzyme Inhibition: Application to Anti-Cancer Drug Design
  Brandeis University, Waltham MA, December 5, 2014
  
  
• Topics: EGFR inhibition by covalent drugs (PNAS, January 2014); Various substrate catalytic mechanisms considered; The effect of association rate constant
  
  PDF handout | PowerPoint presentation

AstraZeneca, September 2014

• Covalent Inhibition Kinetics: Application to EGFR Kinase
  AstraZeneca Global R&D, Alderley Park, U.K., September 23, 2014
  
  
• Topics: EGFR inhibition by covalent drugs (PNAS, January 2014); Data quality control algorithm; Confidence intervals for "on" and "orr" constants
  
  PDF handout | PowerPoint presentation

Brandeis University, March 2014

• Irreversible Inhibition Kinetics: Biochemical Rate Constants vs. Cell-based IC₅₀
  Brandeis University, Waltham MA, March 20, 2014
  
  
• Topics: EGFR inhibition by covalent drugs (PNAS, January 2014); New results using previously published data; PK/PD simulations
  
  PDF handout | PowerPoint presentation

Archive

• Irreversible Inhibition Kinetics: Automation and Simulation
  PDF handout | PowerPoint presentation
  
  
• Numerical Enzymology: Generalized Treatment of Kinetics and Equilibria
  PDF handout | PowerPoint presentation
  
  
• Why IC₅₀'s Are Bad for You and Other Surprises
  PDF handout | PowerPoint presentation
  
  
• Numerical Enzyme Kinetics: Using DynaFit Software
  PDF handout | PowerPoint presentation
  
  
• Biochemical / Biophysical Kinetics Made Easy
  PDF handout | PowerPoint presentation
  
  
• DynaFit in the Analysis of Enzyme Progress Curves: Irreversible Enzyme Inhibition
  PDF handout | PowerPoint presentation
  
  
• Biochemical Kinetics Made Easier: DynaFit Applications to Protein Kinases
  PDF handout | PowerPoint presentation
  
  
• Optimal Experiment Design for Dose-Response Screening of Enzyme Inhibitors
  PDF handout | PowerPoint presentation
  
  
• Evolutionary Computing in the Study of Bio/Chemical Mechanisms
  PDF handout | PowerPoint presentation
  
  
• Bio/Chemical Kinetics Made Easier: A Numerical Approach
  PDF handout | PowerPoint presentation
  
  
• Numerical Enzymology: Generalized Treatment of Kinetics and Equilibria
  PDF handout | PowerPoint presentation
  
  
• Advanced Methods in Dose-Response Screening of Enzyme Inhibitors
  PDF handout | PowerPoint presentation