Important Update
[May 2015]
- A significantly enhanced version of this online tool
was made part of the software package DynaFit.
- See BioKin Technical Note TN-2015-03 for details.
The King-Altman online tool
The King-Altman method [1] has been implemented as an interactive web form.
The user can type a reaction mechanism in a symbolic form, using the usual chemical notation
(e.g., E + S <==> ES ---> E + P) and obtain the result in the algebraic form.
The present implementation of the King-Altman method was inspired by a discussion presented by Cornish-Bowden [2].
All test examples were gathered from an enzyme kinetic textbook by Segel's [3].
- Data Submission Form
-
Use this form to submit a mechanism in the symbolic form to derive the corresponding steady-state rate equation.
- Examples
-
A list of example problems that were used for testing. Copy a given mechanisms and paste it into the data submission form.
- Theory
-
A few notes on the motivation for this tool and on its design (for example, why does the online form not produce Michaelis constants).
References
- King, E. L. and Altman, C. (1956) "A Schematic Method of Deriving the Rate Laws for
Enzyme-Catalyzed Reactions" J. Phys. Chem. 60, 1375-1378.
- Cornish-Bowden, A. (1977) "An automatic method for deriving steady-state rate equations" Biochem. J. 165, 55-59.
- Segel, I. H. (1975) Enzyme Kinetics, John Wiley, New York.
|
