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| Publications |
| Preprints, reprints, working papers, and translations originating at BioKin, Ltd. |
The following is a short list of recent publications (co)authored by Petr Kuzmic, Ph.D. A more comprehensive list is given here.
- Practical Robust Fit of Enzyme Inhibition Data
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A chapter in Methods in Enzymology vol. 383 (publication date: April 2004) describing the application of Huber's Minimax robust regression for fully automated determination of enzyme inhibition constants, including the rejectionof outlier data points.
- Tight-Binding Impurities in Enzyme Inhibitors
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In collaboration with researchers from Celera Genomics, we proposed a new rate equations that can be used to detect the presence of tight-binding impurities in samples of otherwise weakly potent enzyme inhibitors.
- Determination of Enzyme Inhibition Constants
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In this Analytical Biochemistry article, we describe an algorithm for the determination of enzyme inhibition constants, suitable for fully automated secondary screening (dose-response determinations). The algorithm is incorporated in the software PlateKi and BatchKi.
- Complex Mechanism of Factor Xa Inhibition
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Our colleagues at Yale University Medical School isolated a new small-protein inhibitor of Factor Xa from hookworm. In this J. Biol. Chem. article, we have determined an unusual inhibition mechanism distinguished by the following features:
- "tight binding";
- partial hyperbolic mixed-type inhibition;
- two independent binding sites for the inhibitor.
This paper illustrates a useful application of our software DynaFit.
- BIBLIOGRAPHY
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List of selected publications by Petr Kuzmic, Ph.D., President and CEO of BioKin Ltd.
- CITATION ANALYSIS
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List of bibliographic references that contain citations to our publications.
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www.biokin.com/papers/index.html
Fri Jan 18 10:00:31 2008 |
